Mepivacaine B

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Mepivacaine 是一种酰胺型药剂，可暂时使局部失去知觉。Mepivacaine 与神经元细胞膜上特定的电压门控钠离子通道结合，抑制钠离子内流和膜去极化。

Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.

Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action.Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine).Mepivacaine displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels.

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Membrane Transporter/Ion Channel

Sodium Channel

Sodium Channel

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96-88-8

246.35

C15H22N2O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 33.33 mg/mL (135.30 mM; 超声助溶 )

CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C

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(-20℃)

With Ice Pack

≥ 2 years